Journées Nationales du Collège 2000 – Dourdan V – 15-18 Mars – Régulation de la différentiation lympho-plasmocytaire normale et pathologique

Régulation de la différentiation lympho-plasmocytaire normale et pathologique – R. Bataille

Laboratoire d’hématologie, Nantes

In this review, we emphasise the interest of reactive plasmocytoses (RP) in hurnan biology. We and others have characterized RP as in vivo expansions of highly proliferative immature plasma cells (PC), including both PC progenitors i.e., plasmablasts and PC-precursors i.e., early PC, which are discriminated by CD138 (syndecan expression). Furthermore, we and others have shown that these reactive PC progenitors and precursors are totally dependent on Il~6 to survive and thus to expand. FinalIy, reactive PC progenitors retain the capacity to further differentiate in vitro, when they stop to proliferate. Thus, we consider RP as a relevant model to (i) study the rnechanisms of survival, proliferation and then differentiation of human PC (human plasmacytopoiesis) and (ii) better characterize the factors favoring the ernergence of benign and malignant PC disorders, such as Multiple Myeloma (MM).